Table 1 from Nourishing and health benefits of coenzyme Q10 - a review | Semantic Scholar (2024)

Being a natural substance with low toxicity and good efficacy it would be appropriate to recommend CoQ10 as an adjunct to conventional therapy in selected group of patients.

It can be concluded that the interconversion CoQ10⇌QH2 leading to the prevalence of QH2 in biological tissues is responsible for the antioxidant action of coenzyme Q10 in living organisms.

It is proposed that the CoQ10‐NPs have potential capability to be used as a therapeutic and prophylactic agent for poisoning that is induced by organophosphate agents, especially in the case of DDVP.

The present study designed to synthesize ubiquinol acetate, which is more stable and biologically active, and further evaluate its safety and genotoxic potential, and showed better stability than that of ubiqu inol at the end of 3 months.

Evidence supporting the potential hepatotoxic actions resulting from repeated administration of intermediate oral dose of Co-Q10 especially on the long-term is added.

The antioxidant activity of meat components results, among others, from the capability of scavenging reactive oxygen and nitrogen species, forming complexes with metal ions and protecting cells against damage.

Oral administration of CoQ10 inhibited adverse changes in oxidative stress and muscle and liver damage indices in the competition phase of swimming.

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Double-blind placebo-controlled trials have definitely confirmed that coenzyme Q10 has a place as adjunctive treatment in heart failure with beneficial effects on the clinical outcome, the patients' physical activity, and their quality of life.

Evidence for a function in redox control of cell signaling and gene expression is developing from studies on coenzyme Q stimulation of cell growth, inhibition of apoptosis, control of thiol groups, formation of hydrogen peroxide and control of membrane channels.

The molecular action ofα‐TOH in LDL undergoing “mild” radical‐initiated lipid peroxidation is reviewed, and how small levels of CoQ10H2 can represent an efficient antioxidant defence for lipoprotein lipids is discussed.

Positive clinical and haemodynamic effects of oral Q10 supplementation have been observed in double-blind trials, especially in chronic heart failure, and these effects should be further examined.

The availability of genetic testing will allow for a better understanding of the pathogenesis of this disease and early initiation of therapy (even presymptomatically in siblings of patients) in this otherwise life-threatening infantile encephalomyopathy.

This optimized method for CoQ(10)H(2) analysis provides rapid and precise results with the potential for high throughput and is specific and sufficiently sensitive for use in both clinical and research laboratories.

A systematic study for detecting the ubiquinone content in subcellular compartments, cells, and whole-tissue homogenates by a previously standardized HPLC method performed after an extraction procedure identical for all samples.

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